Featured Profile

Dr. Charles Lockwood
Chair of Obstetrics and Gynecology
Yale-New Haven Hospital

Charles J. Lockwood, is the Anita O’Keefe Young Professor of Women’s Health and Chair of the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale University School of Medicine, and Chief of Ob/Gyn at Yale-New Haven Hospital. Prior to joining Yale he was the Stanley H. Kaplan Professor and Chair, Department of Ob/Gyn at NYU School of Medicine in New York. Dr. Lockwood received his undergraduate education at Brown University, where he graduated magna cum laude with special distinction in his field of Biology in 1977. He received his M.D. from the University of Pennsylvania in 1981, where he was president of the graduating class. He completed a residency in Ob/Gyn at the Pennsylvania Hospital in 1985 and a fellowship in Maternal-Fetal Medicine at the Yale-New Haven Hospital in 1987. After spending two years in the Department of Ob/Gyn at Tufts University School of Medicine, he was awarded an American Association of Obstetricians and Gynecologists Foundation (AAOGF) Kennedy-Dannreuther fellowship and worked in the laboratory of Dr. Yale Nemerson, a world-renowned expert in basic coagulation processes, at Mount Sinai School of Medicine from 1989 to 1991. He established his own laboratory in 1991 and subsequently received NIH and private foundation funding which he has expanded and maintained to the present day. At Mount Sinai, he also served as Director of Perinatal Research in that institution’s Department of Ob/Gyn from 1989 until March 1995, at which time he
accepted the Chair of the Department of Obstetrics and Gynecology at the New York University (NYU) School of Medicine.


Notable accomplishments as NYU’s Chair included starting a faculty group practice that ultimately generated $28 million in annual revenue and creating top-rated subspecialty services, including internationally renowned IVF and Prenatal Diagnostic centers. He led dramatic increases in patient volumes and construction of state of the art obstetric facilities at Tisch and Bellevue Hospitals. For 18 months, he served as interim director of NYU’s NCI-designated Comprehensive Cancer Center, where he promulgated radical restructuring of all of NYU’s cancer clinical services and planned the construction of an ambulatory cancer care center. The latter is now second only to Memorial-Sloan Kettering in cancer patient volume in NYC.

He assumed the Chair of Ob/Gyn at Yale University School of Medicine in 2002. Through careful strategic planning and targeted recruitment, the Department has doubled both its NIH grant dollars and clinical revenue in four years. The Department has 189 employees including 77 full time and research faculty, 19 post-doctoral fellows, 14 clinical fellows, 52 clerical and technical staff and 31 management and other professional staff. The Department has 37,000 SF in lab/office and 20,280 SF in clinical space. Departmental grant and contract revenues in FY 2006 were $12,392,304, including $5,532,871 in NIH grant support. The Department ranks 4th in the nation among university departments for total NIH grant support and is tied for 1st for individual grants. In FY 2006, the full time faculty provided 19,888 patient visits, not including over 28,000 prenatal ultrasounds, 1,377 deliveries, 3,497 surgeries, 390 IVF cycles and 1,142 urodynamic tests. The Department is ranked among the top 10 Ob/Gyn departments in the U.S. News and World Report survey. To encourage physician-scientist training he acquired NIH K12-funding for the Yale Women’s Reproductive Health Research Scholars Program. He serves on numerous administrative committees for the School of Medicine, Yale-New-Haven Hospital and the University,
including the Dean’s Advisory Board, the Comprehensive Cancer Center Steering Committee, Executive Committee of the Hospital Medical Board and the Provost’s Budget Committee. He also serves on the Yale Medical Group’s finance, nominating and executive committees and is chair of its contracting committee.

Dr. Lockwood is a member of the Sigma Xi and Alpha Omega Alpha honor societies, and has presented several prize papers at the Society for Maternal-Fetal Medicine. He has garnered multiple teaching awards, has authored 200 peer-reviewed publications, 59 chapters and invited reviews, and 70 editorials. He is the co-editor of three obstetrical textbooks, an ACOG monograph on thrombophilia, as well as the Obstetrical Editor of UpToDate OB/GYN, an Internet-based textbook. He has twice served on the editorial board of the Journal of Clinical Endocrinology and Metabolism and currently serves on the Journal of Perinatal Medicine and is the Editor-in-Chief of Contemporary OB/GYN, which has the largest circulation of any journal in the field. Dr. Lockwood just received his second Jesse H. Neal National Business Journalism Award for his editorials in Contemporary Ob/Gyn. He is also an associate editor of the Journal of Maternal Fetal & Neonatal Medicine.

His service to professional organizations includes work as the past Chair of the American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetrical Practice as well as its Document Review Committee for Obstetrics. He has also been a liaison member of ACOG’s Obstetrical Practice Bulletin and Genetics committees. He has served as ACOG’s representative to the CDC Workgroup on Low Birth Weight, the
American Academy of Pediatrics Committee on the Newborn and the American Medical Association’s Workgroup on Prenatal Testing. He has also served on multiple committees for FASEB. He is currently President of the Society for Gynecologic Investigation (SGI), the leading international society of reproductive scientists. He previously served on the SGI Council, as Secretary-Treasurer of the SGI. He has served as
a regular member, and currently as Acting Chair, of the FDA’s Reproductive Health Drugs Advisory Committee Panel, which has dealt with such controversial issues as over-the-counter approval of the Plan B emergency contraceptive and the female testosterone patch for treatment of decreased libido. He is committed to the training of ob/gyn physician scientists as demonstrated by his service as Chair of the AAOGF Endowment Fund Committee that sponsors six physician-scientist training fellowships and by his service on the NICHD’s Reproductive Scientist Development Program Selection Committee. He has served as a regular and ad hoc member of various NIH study sections, including Human Embryology and Development (HED)-1 and Pregnancy & Neonatology (PN). He has presented to two Institute of Medicine (IOM) committees on the pathogenesis of preterm delivery and testified before the U.S. Senate on the impact of prematurity.

Dr. Lockwood’s primary research interests include the regulation of endometrial and decidual hemostasis and angiogenesis, the pathogenesis of adverse pregnancy outcomes associated with maternal inherited thrombophilias and antiphospholipid antibody syndrome, and the pathogenesis and prediction of preterm delivery. Notable discoveries by the lab include elucidation of molecular mechanisms underlying endometrial hemostasis, menstruation, contraceptive-associated uterine bleeding and abruption-associated preterm delivery. He helped discover that the presence of vaginal fetal fibronectin predicted preterm birth. This latter work resulted in subsequent FDA approval and current widespread clinical use. His current research is supported by multiple R01 and a project on a U54 center grant, one in its 12th year. He has also received grant support from the March of Dimes for eight years.

In addition to his research, teaching and administrative responsibilities, Dr. Lockwood maintains a faculty practice in high risk obstetrics, delivering patients, conducting consultations, ultrasounds and performing chorionic villus sampling, amniocenteses and intrauterine transfusions. He has been cited on the “Best Doctors” list by American Health Magazine and has been annually cited as a "Best Doctor" by New York Magazine and the Castle and Connolly Survey for the last 12 years.

Recent Contributions by Dr. Charles Lockwood